Magic power of phosphoinositide 3-kinase inhibitors
Phosphoinositide 3-kinases (PI3K) play critical roles in the maintenance of cell biological functions and are suggested as a therapeutic target for drug discovery and development. PI3K inhibitors has the magic power to prevent the development of pathological changes and cure the diseases, while such magic powers can be faded by the large profile of their toxicity and side-effects. A number of strategies can prevent, reduce, or decline PI3K inhibitor-associated toxicities, e.g. to make the inhibitors targeting the core molecules more precisely, select the optimal approach of drug delivery, bind the “recognizing” pullets with PI3K inhibitors to target-specific cells, or gene editing. We spotlight that PI3K definitely is an important therapeutic targets for cancer, inflammation, or organ dysfunction and injury, while to catch and hold such magic power of PI3K inhibitors is still the challenge to be faced and solved.