Magic power of phosphoinositide 3-kinase inhibitors

PI3K inhibitor

  • Xiangdong Wang Shanghai Institute of Clinical Bioinformatics
DOI: 10.26781/2052-8426-2017-01

Abstract

Phosphoinositide 3-kinases (PI3K) play critical roles in the maintenance of cell biological functions and are suggested as a therapeutic target for drug discovery and development. PI3K inhibitors has the magic power to prevent the development of pathological changes and cure the diseases, while such magic powers can be faded by the large profile of their toxicity and side-effects. A number of strategies can prevent, reduce, or decline PI3K inhibitor-associated toxicities, e.g. to make the inhibitors targeting the core molecules more precisely, select the optimal approach of drug delivery, bind the “recognizing” pullets with PI3K inhibitors to target-specific cells, or gene editing. We spotlight that PI3K definitely is an important therapeutic targets for cancer, inflammation, or organ dysfunction and injury, while to catch and hold such magic power of PI3K inhibitors is still the challenge to be faced and solved.

Author Biography

Xiangdong Wang, Shanghai Institute of Clinical Bioinformatics

Xiangdong Wang, Professor of Medicine and Clinical Bioinformatics, Fudan university, China

 

Xiangdong Wang, MD, PhD, is a Distinguished Professor of Medicine at Fudan University, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Director of Fudan University Center of Clinical Bioinformatics, Deputy Director of Shanghai Respiratory Research Institute, and visiting professor of King’s College of London. He serves as the deputy president of National Committee of Clinical Precision Medicine, Chinese Medical Doctor Association.

His main research is focused on clinical bioinformatics, disease-specific biomarkers, lung chronic diseases, cancer immunology, and molecular & cellular therapies. He is the author of more than 200 scientific publications with the impact factor about 900, citation number about 6820, h-index 46, i10-index 180, and cited journal impact factor about 8000.

 

Keywords

PI3K, Inhibitor, drug discovery, cancer, lung
Published
2017-09-07
How to Cite
WANG, Xiangdong. Magic power of phosphoinositide 3-kinase inhibitors. Molecular and Cellular Therapies, [S.l.], v. 5, n. 1, sep. 2017. ISSN 2052-8426. Available at: <http://molcelltherapies.com/article/view/113>. Date accessed: 18 oct. 2017. doi: https://doi.org/10.26781/2052-8426-2017-01.