Can p53 be a therapeutic target?
Drs Kastenhuber and Lowe recently published an article entitled "Putting p53 in Context" in Cell (Cell. 2017 Sep 7;170(6):1062-1078). TP53 is an important molecule to maintain the normality of cell biology and has been suggested as one of the most important targets for diagnostics and therapies. The frequency of TP53 mutation is the highest one in mutated genes in human cancer. TP53 is also the core gene within gene networks leading a large number of biological functions. Drs Kastenhuber and Lowe conclude “p53’s disparate activities and the consequences of its dysfunction to understand how cell type, mutation profile, and epigenetic cell state dictate outcomes, and how might we restore its tumor-suppressive activities in cancer?”